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This suppression may be attributed to the reduced activity and gene expression of cholesterol 7a hydroxylase, a key enzyme for CDCA synthesis, in conventionally fed mice, which results in a decrease in the level of muriatic acid produced by hydroxylation of CDCA in liver microsomes
& Costello, R
The biology is also slow, as we need months of follow-up to prove true regrowth, not just reduced shedding, which makes trials expensive and long
Depression and advanced complications of diabetes: a prospective cohort study
Clin Med Insights Reprod Health 2019
