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In six CVOTs, GLP1-RA reduced the risk of the broad composite kidney outcome by 17% (HR = 0.83, Fig
Glucagon-like peptide-1 analogues: an overview
Incretin action in the pancreas: potential promise, possible perils, and pathological pitfalls
By modifying the primary sequence of OXM and linking to the constant region of human IgG4, Jung and colleagues demonstrated their peptide HM12525A had a potent and balanced activity at both GLP-1 and glucagon receptors in vitro and led to body weight loss of 30% in DIO mice over 14 days compared to liraglutide treated mice (74)
Am J Pathol 182:132141
