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In adult animals, GLP1RAs reach the brain via circumventricular organs, which lack a fully formed bloodbrain barrier (BBB)

3.6.3 Weight changes Concerning weight change, transitioning from Dulaglutide to Semaglutide resulted in a pooled effect size of 1.38 (95% CI: 4.25, 7.01

That can narrow your blood vessels, which might limit blood flow to your optic nerve
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