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Clinical studies suggest that a significant proportion of weight lost during caloric restriction can come from lean tissue

Genetic predispositions in GLP-1 receptor signaling, appetite regulation, and metabolic pathways (variants in GLP1R, GIPR, FTO, and MC4R genes) may correlate with individual response patterns

[DOI] [PubMed] [Google Scholar] 114.Caussy C., Aubin A., Loomba R