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These factors often raise the odds: Low daily fluid intake

The medication spends the night in a bag by the front door or on the bedroom floor

Research has observed changes in gut microbiota composition with GLP-1 receptor agonist therapy, though the clinical significance remains under investigation and these effects should be considered preliminary rather than established mechanisms for digestive symptoms

Drop 100-plus pounds and sagging skin is likely

It is important to emphasize that current evidence does not support prescribing GLP-1 medications specifically for substance use disorders outside of research settings