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W., Loghin C., et al., LY3298176, a Novel Dual GIP and GLP1 Receptor Agonist for the Treatment of Type 2 Diabetes Mellitus: From Discovery to Clinical Proof of Concept, Molecular Metabolism 18 (2018): 314
Nearly 9 out of 10 participants lost at least 5% of their body weight, a threshold that clinical guidelines consider meaningful for reducing cardiovascular risk, improving metabolic markers, and alleviating joint stress
And a growing number cannot get it at all, whether because of supply constraints, insurance denials, side effects that make the drug unbearable, or a medical history that rules it out entirely
Each patient will start to notice the effects of their peptides several weeks after starting treatment
That figure changed the entire conversation around pharmaceutical weight management
