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There is considerable interest in pairing GLP-1R agonism with glucagon receptor agonism to enhance both energy expenditure to maximize weight loss and potentially leverage the lipid oxidative properties of glucagon in hepatocytes to target nonalcoholic fatty liver disease

Diabetes, Obesity and Metabolism, 24 (8), 1553-1564
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14 Jastreboff, A.M., et al., Tirzepatide Once Weekly for the Treatment of Obesity
