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6 According to this new framework, people with a BMI of 25 or higher would be classified as having obesity if they also: Have a waist-to-height ratio of 0.5 or greater Have been diagnosed with medical, functional, or psychological issues related to excess body fat, such as elevated blood glucose, chronic low-grade inflammation, poor sleep, or binge eating

Di Meo, F., Margarucci, S., Galderisi, U., Crispi, S

In most cases, levels are extremely low or clinically insignificant after about 45 weeks

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There's no need to restart from the lowest dose again