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We have further shown that this effect could originate from the hypothalamus, as a dual agonist of GLP-1RA with GIP had a synergetic effect in decreasing feeding behavior compared to GLP-1 or GIP alone when delivered to the hypothalamus in an ICV manner [83]

Long term risks While tirzepatide and semaglutide are effective in aiding weight loss, there are some long-term risks to be aware of

Cevimeline is another prescription sialagogue that works through a similar mechanism but with potentially fewer cardiovascular side effects than pilocarpine

Importantly, phentermine and semaglutide side effects can overlap in practical ways

The key finding of a 7% survival benefit in patients who continued metformin challenges the current dogma