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In individuals with T2D, epigenetic modifications, specifically increased DNA methylation of the GLP-1R gene, reduce receptor expression, impairing the function of GLP-1 and lowering insulin secretion

The immunohistochemical results showed that the expression of GLP-1R was down-regulated and the expression of STING, ACSL4 and TNF- was up-regulated in the RA group compared to the NC group

For example, while GLP-1 RAs carry a low intrinsic risk of hypoglycemia, the addition of a GLP-1 RA to background sulfonylurea or insulin therapy can increase the risk for treatment-emergent hypoglycemia

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