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In order to minimise the variability in hormone levels and other factors that might affect the pharmacokinetic response, only male subjects were included in the current trials

By contrast, physiological levels of GLP-1 in the portal vein signal through vagal afferents and neurons in the nucleus tractus solitarius (NTS) (3)

Giri D, Alsaffar H, Ramakrishnan R

Patients with a history of pancreatitis, certain thyroid cancers, or severe gastrointestinal disease may need alternative therapies

Communicate openly with your healthcare provider about your experience so they can help you find the right approach
