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Salas Whalen puts it very directly

The liver was doing about eight times more of the weight-change work than the muscle was

Thigh injections produced roughly half the rate of nausea compared to abdominal injections
If you take acid reducers (like PPIs or H2 blockers), probiotics may survive differently: consistency matters more than "perfect timing." Separate probiotics from antibiotics by a few hours when possible (and continue the probiotic for a short period after finishing antibiotics, if your clinician agrees)

Reduce excess glucose production by the liver
