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doi:10.1016/S0014-5793(01)02968-4 92

While studies on initial combination therapy have not yet directly demonstrated a reduction in long-term complications, the well-established benefits of tight glycemic control suggest that early combination therapy may contribute to lower complication rates in the future

2021;11:e01960

Currently, AMG-133 is undergoing a phase 2 clinical trial in adults with a BMI of 25 (overweight) or 30 (obese) and obesity-related metabolic disorders, including type 2 diabetes

Both Wegovy and Ozempic, which mimic the hormone GLP-1, are given as weekly injections, as are rival drugs from Eli Lilly, called Zepbound and Mounjaro