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Severe depression or active suicidal thoughts The MHRA, FDA, and EMA have reviewed the evidence and found no causal link between GLP-1 medications and suicidal thoughts or behaviour

Comparing sodium-glucose cotransporter 2 inhibitors and dipeptidyl peptidase-4 inhibitors on new-onset depression: a propensity score-matched study in Hong Kong

Dulaglutide utilises a large recombinant fusion protein with Fc fragment for prolonged action, achieving a 5-day half-life with once-weekly dosing [29]

20 A large UK cohort (9 239 females, 556 males) found higher fracture risk in females across all ages (HR = 1.59) and in males over 40 (HR = 2.54), with hip/femur and pelvis most affected in females, vertebrae in males

However, assessment of body composition in both of these studies revealed that the absence of GIPR signaling in adipocytes contributes to reduced lean mass, but not fat mass