how much better is tirzepatide than semaglutide vs Tirzepatide: Head-to-Head for Weight Loss & Diabetes Tirzepatide vs Semaglutide Compared |

Oeseburg H, de Boer RA, Buikema H, van der Harst P, van Gilst WH, Sillje HHW

All studies were multicenter RCTs conducted over durations ranging from 52 to 104 weeks

Training and Awareness: Employers and healthcare providers should be well-informed about the implications of using semaglutide, including its benefits and how it should be treated in the context of drug testing

That said, the Wegovy HD 7.2mg dose (approved March 2026) produced 20.7% in the STEP UP trial, which puts it very close to tirzepatide territory

If you have had gallstones before, even if they resolved, your risk of recurrence is substantially higher