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doi: 10.1016/S0140-6736(14)60976-4 232 HannonTSArslanianSA

Weeks 1-4: 0.25mg weekly subcutaneous injection Weeks 5-8: 0.5mg weekly subcutaneous injection Weeks 9-12: 1.0mg weekly subcutaneous injection Weeks 13+: 1.0mg maintenance or increase to 1.7-2.4mg based on response The starting dose of 0.25mg per week produces minimal appetite suppression but allows gastrointestinal adaptation

Whether the clinical efficacy of GLP-1 medicines in these conditions is primarily mediated by weight loss or by additional mechanisms such as improved insulin sensitivity, restoration of metabolic control and reduced inflammation remains an open question (Figure 1B), since most large clinical trials are not designed to elucidate the underlying molecular mechanism

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