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Lipedema fat is progressively encased in fibrosis, scar tissue built inside the tissue itself

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Its main physiological roles include stimulating insulin release in a glucose-dependent manner, suppressing glucagon, slowing gastric emptying, and reducing appetite

Additionally, the GLP-1R/glucose-dependent insulinotropic polypeptide receptor (GIPR) dual agonist tirzepatide can induce weight loss of 10%20%, and the results of the ongoing SURPASS-CVOT trial may provide more clarity on whether weight loss itself is an independent driver of CV protection (74)