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At 208 weeks, semaglutide was associated with mean reduction in weight (10.2%), waist circumference (7.7 cm) and waist-to-height ratio (6.9%) versus placebo (1.5%, 1.3 cm and 1.0%, respectively

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Mazdutides reported weight-loss figures (up to 16.65% at 60 weeks) are in a broadly similar range to semaglutides pivotal trial results (around 15% at 68 weeks), though the two compounds havent been compared in the same trial with matched populations