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Digestive enzymes are not a standard, evidence-backed treatment for these side effects, so current guidance focuses on dose titration, smaller low-fat meals, hydration, and sometimes anti-nausea meds.43 However, some clinicians and patients are experimenting with broad-spectrum enzyme blends to see if meals feel less stuck, but this use is based on clinical experience rather than trials, so its important to loop in your prescriber before trying enzymes alongside a GLP-1

These studies involve thousands of participants and carefully track both effectiveness and safety outcomes

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