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Description
GLP-1RAs, glucagon-like-peptide-1 receptor agonists

cAMP-dependent protein kinase and lipolysis in rat adipocytes

In addition, some putative effects of GLP-1RAs on cognitive and mental health symptoms may not require direct activity in the CNS, but rather be mediated by the actions that these medications express in the periphery across immune, endocrinemetabolic and gutbrain axis mechanisms (Fig

Although an endogenous OXM receptor has not been identified, OXM exerts weak agonist activity on GLP-1R (106) and the glucagon receptor (GCGR) (107)

Caution is advised in patients with depression and suicidality [153]
