glp 1 agonist vs sglt2 inhibitor inhibitors or GLP-1 receptor agonists as second-line therapy in | VHRM Kidney and Cardiovascular Effectiveness of
Description
Biochem Biophys Res Commun 223: 624-632, 1996
The profound influence of GLP-1 receptor agonists on cardiovascular outcomes has been elucidated through a series of CVOTs
Some investigators have proposed that GLP-1RAs improve myocardial insulin sensitivity, enhance glucose oxidation rates, reduce fatty acid oxidation, and thereby optimize myocardial energy metabolism, ultimately improving cardiac function.106 In a randomized controlled trial (RCT) conducted by Mikhail et al,106 semaglutide efficacy was evaluated in 616 patients with obesity-related heart failure and T2DM
Furthermore, hospital pharmacies often manage the dispensing of injectable medications requiring specific storage and handling, which is the case for many GLP-1 receptor agonists
Monami et al evaluated changes in lipid levels with GLP-1RA versus placebo in a meta-analysis
