why is tirzepatide dose higher than semaglutide vs Tirzepatide: Which Better for Weight Loss? Tirzepatide versus Semaglutide Once Weekly

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They propose based on rodent and monkey studies that this kind of molecule, when administered at high enough doses, may result in weight loss comparable to the weight loss seen with drugs that include GLP-1 as a target, and without the tolerability issues like nausea and vomiting that often come with the approved treatments, according to a peer-reviewed draft paper published this week

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Every four weeks, the dose typically increases by 0.25 mg incrementsprogressing from 0.25 mg to 0.5 mg to 0.75 mg to 1.0 mg over the first 16 weeks of treatment