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doi: 10.1038/s41582-019-0227-8

For a medicine to receive UK marketing authorisation, the manufacturer must submit a comprehensive dossier of evidence including Phase 3 clinical trial data demonstrating that the product meets the required standards of safety, efficacy, and quality

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For example, in the STEP 1 trial, participants receiving semaglutide 2.4 mg weekly showed improvements in insulin sensitivity markers that correlated with the degree of weight loss achieved after 68 weeks of treatment