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These FDA-approved medications work systemically through receptor activation rather than requiring gallbladder function, making them viable options for patients without this organ

Finally, the increasing off-label use of GLP-1 RAs for weight loss in non-diabetic individuals may further exacerbate access limitations and drug shortages, potentially disadvantaging patients with T2DM

Studies have also shown that these drugs interact with other parts of the body, potentially reducing the risk of health conditions such as kidney disease, cardiovascular diseases, and heart attacks

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