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In gastric bypass-operated individuals with obesity and no history of diabetes, GIP(3-30)NH 2 does not affect insulin secretion nor plasma glucose levels (79)

Several lines of evidence indicate that NAcc GLP-1R activation decreases food intake by reducing food palatability

The result is that GI effects that were prominent in week one diminish by week four, even though drug levels are actually higher by week four than week one

Not unimportant, in the perioperative period, the use of GLP-1 and GIP/GLP-1 receptor agonists may be associated with an increased risk of regurgitation and aspiration of gastric contents into the lungs during induction of general anesthesia due to delayed emptying and retention of gastric contents

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