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Risk factors for addiction include a history of substance abuse, mental health disorders, and genetic predisposition

These findings suggest that neither direct release of GLP-1 in the OB from hindbrain PPG neuron projections, nor volume transmission via release of GLP-1 into the ventricles are likely sources of GLP-1 to activate OB GLP-1R

Both compounds improve insulin sensitivity, but through partially overlapping and partially distinct mechanisms

AMPK activation increases glucose transporter GLUT4 translocation to cell surfaces, improving insulin-independent glucose uptake by 2040% in vitro (PMID: 18442638)
