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In fact, because of the scale of prescribing for obesity, far more people with alcohol use disorder (AUD) are already taking GLP-1s than existing indicated anti-addiction medications, as we examine below

Scand J Gastroenterol

And the TMD is responsible for further interaction with the N-terminus of the ligand, which triggers receptor activation (Ma et al., 2020)

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Fatigue is common in both undertreated hypothyroidism and early tirzepatide use, and the combination can feel overwhelming if both are contributing