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Compounds 47 and 48 (Figure 6), with IC 50 values of 0.83 and 0.43 M, respectively, which possess aryl-substituted piperazines with acetamide linkers, showed the best activity as DPP-4 inhibitors

Bu H, Li L, Li X, Guo J

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Novo Nordisk is sticking close to home for its latest GLP-1 deal, signing a $285 million partnership with fellow Danish company Ascendis Pharma to work on new therapeutics for metabolic and cardiovascular diseases