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Quick Answer: Semaglutide causes diarrhea by activating GLP-1 receptors in the gastrointestinal tract, which alters gut motility, slows gastric emptying, and disrupts normal digestive processes
The request comes after a safety review that analyzed nearly 100 placebo-controlled clinical trials with over 106,000 patients and found no increased risk of suicidal thoughts or behavior related to GLP-1 use
hence, its dose should not be changed in renal impaired patients [24]
The ~15% weight loss observed with semaglutide approaches the 2030% weight loss achieved through bariatric surgery
