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Kroller-Schon S, Knorr M, Hausding M, Oelze M, Schuff A, Schell R, Sudowe S, Scholz A, Daub S, Karbach S, et al

Similar antagonistic effects of GRAs on GLP-1(936)s glucagonostatic effects were observed in human islets using the antagonists desHis 1 Pro 4 Glu 9 glucagon (peptide N) or desHis 1 Pro 4 Glu 9 Lys 12 PAL-glucagon (peptide R) [47] (ESM Fig

These results support the notion that a higher degree of leptin reduction in diet-induced obese mice is beneficial and synergizes with GLP-1R agonism to yield a more dramatic weight loss
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