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Adequate protein supports muscle mass, maintains metabolic rate, aids recovery, and promotes overall health during weight loss

In the placebo group, typical total consumption over 30 days declined by 46%, much less but still a substantial amount, reflecting the placebo effect, the desire to reduce drinking, and the fact that participants received CBT therapy over the course of the trial

These symptoms could indicate dehydration severe enough to affect cardiovascular function, electrolyte imbalances reaching dangerous levels, thyroid dysfunction, or other conditions that require medical intervention

Summary: Retatrutide is an investigational triple receptor agonist (GLP-1, GIP, and glucagon) that, based on Phase 2 trial data, produces significant appetite suppression and progressive weight loss, alongside gastrointestinal side effects that are most prominent during dose escalation