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8 Conclusion and future prospective The use of incretin-based therapy, particularly GLP-1 receptor agonists, has exhibited encouraging outcomes in addressing obesity and associated conditions such as diabetes mellitus type-2, cardiovascular disease, and NAFLD (non-alcoholic fatty liver disease)

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The difference is the indication on the label

Tirzepatide, the newest medication for type 2 diabetes: A review of the literature and implications for clinical practice

A 2025 meta-analysis in PMC (covering 36,754 tirzepatide and 106,057 semaglutide participants across multiple studies) confirmed tirzepatides advantage, finding an average 4.23 percentage points greater weight loss with tirzepatide an effect that was both dose- and duration-dependent