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PD symptoms significantly improved, including motor function assessed by the Movement Disorder Society-Unified Parkinsons Disease Rating Score (MDS-UPDRS) Part III motor scores and cognitive function assessed by the Mattis Dementia Rating Scale-2 (Mattis DRS-2)

110,111 Despite GSKs attempts to gain a competitive edge through low pricing, Tanzeum failed to achieve sufficient market acceptance

Recent Developments: 2025: Eli Lilly received FDA approval for tirzepatide (Zepbound) as a treatment for moderate-to-severe obstructive sleep apnea in adults with obesity the first pharmacotherapy approved for this indication expanding tirzepatide's approved uses beyond metabolic conditions into a respiratory indication affecting over 30 million Americans and supported by SURMOUNT-OSA trial data showing 63% reduction in apnea-hypopnea index

Occasionally, GLP-1s affect intestinal motility or secretions, contributing to diarrhea [44]

CagriSema (cagrilintide/semaglutide) Pending Approval - A combination injectable medication in development, combining cagrilintide and semaglutide to enhance weight loss through appetite suppression