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Repeated ICV Administration of Oxyntomodulin Causes a Greater Reduction in Body Weight Gain Than in Pair-Fed Rats

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Thus, clinical trials are needed to establish the benefits/risk profile in HF, considering that no properly designed, HF-specific randomised clinical trials have been completed with GLP-1 RAs in any of the HF phenotypes

Research suggests berberine may help support healthy blood sugar levels while potentially increasing GLP-1 hormone production