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Effect of a low free sugar diet vs usual diet on nonalcoholic fatty liver disease in adolescent boys: a randomized clinical trial

To find out, he began giving exendin-4 to mice that had been made diabetic through overeatingand what he found was astonishing

doi: 10.1016/j.biopha.2024.117202 [DOI] [PubMed] [Google Scholar] 104.He X, Wen S, Tang X, et al

As a result, since 2008, the FDA has required all new drugs for glycemic control in T2DM patients to demonstrate cardiovascular safety

However, controversy still exists as to whether it is best to therapeutically promote or inhibit GIP action for beneficial effects on glycemic control and body weight [[929], [930], [931]] as both GIPR agonists [932] and antagonists [933,934] have decreased body weight in preclinical studies as individual treatments, but also to induce synergistic body weight loss when combined with GLP-1R agonists