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It all plays a role in weight gain. The Centers for Disease Control and Prevention estimates that in 2024, more than 25% of people with diabetes used a GLP-1

Method A literature search was performed in PubMed/MEDLINE, Scopus, Web of Science, and Google Scholar during March 2025September 2025, using combinations of the following terms: GLP-1 receptor, GLP-1R agonist, GLP-1 signalling, semaglutide, liraglutide, exenatide, dulaglutide, salivary glands, xerostomia, hyposalivation, oral adverse effects, biased agonism, -arrestin, cAMP, GPCR signaling, albumin binding, pharmacovigilance

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