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Efficacy and safety of once-weekly glucagon-like peptide 1 receptor agonist albiglutide (HARMONY 1 trial): 52-week primary endpoint results from a randomized, double-blind, placebo-controlled trial in patients with type 2 diabetes mellitus not controlled on pioglitazone, with or without Metformin

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depending on the nature and degree of nutrients absorbed from food by the ileum, the L cells will release the gut peptides PYY and GLP-1