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3,12 The 2005 International Diabetes Federation (IDF) guidelines proposed metformin as first-line therapy, sulfonylureas as second-line add-on to metformin, and thiazolidinediones as potential add-on therapy to metformin with or without sulfonylureas

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So far it has been thought that these crystals are removed by crossing the epithelial barrier to enter the interstitial space and either be reabsorbed by the body or form larger stones

Hypertension: a harbinger of stroke and dementia