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Gastrointestinal adverse events (nausea, vomiting, constipation, diarrhea) scale with dose in the STEP program, and about 4.5% of patients discontinue for GI reasons on 2.4 mg semaglutide (Wilding et al., NEJM 2021)

The broader question of comparing these two peptides is covered in our comprehensive semaglutide versus tirzepatide comparison and side effect comparison

For many, this means dramatic weight loss often 1520% of body weight as well as improved blood sugar control

Does indoor cyclings calorie-burning role in weight management still apply when used alongside weight-loss drugs

However, like all medications, GLP-1 drugs carry risks