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The medication also signals your brain's satiety center more strongly than older GLP-1-only drugs, which can intensify feelings of fullness and reduce appetite beyond what your body is used to

Seek urgent medical attention if you develop jaundice, severe abdominal pain, dark urine, pale stools, or fever whilst taking these medications

"That could yield the superiority," Lontoft said

Elderly patients may experience differential responses to GLP-1R agonists due to age-related changes in GLP1R expression, tumor microenvironment, and systemic physiology
