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Water, saline, tirzepatide at any concentration, it does not matter
10.1111/j.1463-1326.2012.01618.x [DOI] [PMC free article] [PubMed] [Google Scholar] Shaman A

GLP-1R in the Hypothalamus GLP-1R neurons in the arcuate nucleus co-localize with pro-opiomelanocortin (POMC) cells
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doi: 10.1038/nature18324
