glp-1 drugs review The New Current Insights, Advantages and Challenges

The introduction of insulin in type 2 diabetes mellitus

[DOI] [PubMed] [Google Scholar] 100.Drucker DJ

In alzheimers disease, 6-month treatment with GLP-1 analog prevents decline of brain glucose metabolism: randomized, Placebo-Controlled, double-blind clinical trial

The primary mechanisms of action include: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner, meaning insulin is only released when blood glucose levels are elevated Suppressing glucagon release from pancreatic alpha cells, which reduces hepatic glucose production Slowing gastric emptying , which helps moderate post-meal blood glucose spikes Reducing appetite through central nervous system effects, leading to decreased caloric intake and weight loss Examples of GLP-1 receptor agonists available in the UK include exenatide (Byetta, Bydureon), liraglutide (Victoza for diabetes, Saxenda for weight management), dulaglutide (Trulicity), lixisenatide (Lyxumia), and semaglutide (Ozempic/Rybelsus for diabetes, Wegovy for weight management)

doi:10.1016/j.ajo.2024.04.010 20