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doi: 10.1677/JOE-08-0085

Three months provides insufficient time for many patients to reach their target dose and fully experience appetite normalizationthe state where hunger cues genuinely decrease rather than feeling artificially suppressed

The oral GLP-1 medications have a shorter clinical history, and longer-term real-world data is still being gathered

As of May 2026, FDA has also proposed excluding semaglutide, tirzepatide, and liraglutide from the 503B Bulks List, after stating that it did not identify a clinical need for outsourcing facilities to compound these drugs from bulk substances when FDA-approved versions are available

If you suspect this occurred, contact your PlexusDx provider immediatelythey may adjust your dose timing or schedule
