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Research Overview Understanding the Triple-Receptor Mechanism Retatrutide is the first clinically advanced peptide engineered for balanced agonism at three class B G protein-coupled receptors simultaneously: the glucagon-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR)

Renoprotection of dapagliflozin in human renal proximal tubular cells via the inhibition of the high mobility group box 1-receptor for advanced glycation products-nuclear factor-B signaling pathway

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Patients with obesity and/or T2D often experience a decline in SKM coupled with functional deterioration and muscle atrophy, a condition called sarcopenic obesity (SOB) [170]