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However, caution should be used when interpreting these data because the grading system used to evaluate CRS in these trialsthe National Cancer Institute Common Terminology Criteria for Adverse Eventshas been shown to be inconsistently applied by investigators [133]

Some people may experience increased nausea when switching to a GLP-1-only drug because they lose the GIP-mediated nausea buffering that Retatrutide provides

This is where the difference between types of diabetes is important

The lack of data regarding exposure specifically during the first trimester is unfortunate

Over time, as patients transition to more balanced or protein-heavy diets with fewer simple carbohydrates, GLP-1 response may diminish