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Tirzepatide is sold as Zepbound in the US, and retatrutide is a GLP-1 that is still in clinical development and banned in the UK

Importantly, this may not be absolute as growing evidence supports nuclei and/or celltype specific effects of GLP1 or GLP1 receptor agonists (with some action within the hypothalamus) to contribute to the regulation of glucose homeostasis (discussed further below)

Clinical experience suggests that the maximum dose range of semaglutide (2.4 mg) roughly corresponds to the 10-15 mg range of tirzepatide, but individual response varies significantly

They are administered through small subcutaneous injections similar to insulin shots

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