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Patients with lower genetic predisposition for GLP-1R engagement, for example, may theoretically tolerate or benefit from tirzepatide's dual-receptor strategy more effectively

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On average, patients lost eight kilograms (17.5 lbs) at 50 milligrams, which is nearly twice as much weight loss that we saw with the lowest dose. The new study is in line with other studies, which are pushing for the use of oral GLP-1 receptor agonists as a treatment for obesity

The changes could be caused by metabolism, blood sugar, or drug reactions

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