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Kidney problems: May lead to dehydration and worsen kidney function in patients with pre-existing kidney conditions
In the postprandial state, insulin signaling activates LPL, a key mediator of the intake of triglyceride-derived fatty acids into cells
But there are concerns that the drug might not be covered under insurance when used to treat obesity
With Eli Lilly unable to keep up with demand, tirzepatide was added to the official shortages list
