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Think of these as the villains of your lab fridge

We report our methods and results in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement [13]

Osmotic vs stimulant laxatives (OTC options) First-line pharmacologic option: Polyethylene glycol (PEG 3350) is recommended by gastroenterology guidelines because it increases stool water content, improves stool frequency, and is generally well tolerated for ongoing use. Alternative osmotic option: Magnesium oxide may help some patients and is conditionally recommended in gastroenterology society guidance

It also encourages feelings of fullness, which can help reduce cravings and support consistent, long-term wellness as part of a balanced lifestyle

The research team can guide potential participants through the process, answer questions about the risks and benefits, and help determine whether this study or another trial in their network might be a good fit.