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Clare Hambling, Chair, PCDS Ketan Dhatariya, Chair, ABCD This joint guidance from the PCDS and ABCD aims to support clinicians in selecting alternative glucose-lowering therapies when GLP-1 RAs are unavailable during this period of national shortage

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Dose timing of Ozempic (weekly injection) doesnt strongly affect overnight urination

Patients with a personal or family history of medullary thyroid carcinoma or MEN2 syndrome should not use these medications at all

In this study, we report a new two-step cleavage strategy for obtaining semaglutide main chain P29 (Arg 34 GLP-1 (937)), which is a key intermediate precursor in semaglutide synthesis, to form a scalable platform to improve semaglutide yield (Table 1)